DE-YU XIE Ph.D

DE-YU XIE Ph.D
DE-YU XIE Ph.D

Conferencia: Medicinal Plants for the Human Health: Pathways from Traditional Uses to Western Medicines and Solutions for Preservation.
Ph.D. Plant Physiology and Plant Molecular Biology, M.S., Cytogenetics, B.S., Biology Department of Biology, Hunan Jishou University.
Professor, Department of Plant and Microbial Biology, North Carolina State University.
President, the Phytochemical Society of North America, Aug. 2018- July 2019.

My research interests center on structure, biosynthesis, and metabolic engineering of natural products to produce pharmaceuticals for human health and to engineer natural chemicals for biofuel. My current projects include two themes, 1) biosynthesis and metabolic engineering of flavan-3-ols, proanthocyanidins (PAs), anthocyanins, flavonols, artemisinin, terpenoids, and alkaloids; 2) synthetic biology of natural products. To date, my research has contributed a few breakthroughs in PAs, flavan-3-ols and artemisinin. PAs are oligomeric or polymeric flavan-3-ols (monomers of PAs). Their biosynthesis was unknown until 2003, when I discovered a novel pathway, named as anthocyanidin synthesis (ANR) pathway. Next, we demonstrated that the ANR pathway is evolutionally conserved in the plant kingdom. Then, we succeeded in metabolic engineering of flavan-3-ols and PAs in plants.
Artemisinin-combination therapy forms the first line of malarial treatment. Since 1990, my research has contributed a few discoveries in understanding the artemisinin biosynthesis and promoting metabolic engineering for high production of this medicine. These discoveries include: 1) diploid characterization of Artemisia annua-antimalarial plants, 2) the first time of crystallization of artemisinin from transgenic plant materials, 3) innovation of self-pollination of A. annua for high production of artemisinin, artemisinic acid, arteanuin b, and other compounds, 4) determination of a metabolic network controlling the artemisinin pathway, 5) mass-spectrum imaging of artemisinin and its derivatives in cells, 6) discovery of new cell types that express the artemisinin pathway and correction of the dogma of artemisinin biosynthesis (this work was highlighted by Nature News in 2019). My lab has been granted approximately $12,000,000 to study these projects.
I am interested in teaching, mentoring, and training undergraduate students, graduate student, postdocs, and visiting scientists in plant secondary metabolism and medicinal plants. To date, my lab has completed or is training11 PhD or MS students, 11 postdocs, one Borlaug Fellow, 22 visiting scientists, 4 REU students, and 43 undergraduate students, and 8 high school students.

Last Publications:
  1. Xinlong Dai, Yajun Liu, Juhua Zhuang, Shengbo Yao, Li Liu, Xiaolan Jiang, Kang Zhou, Yunsheng Wang, Deyu Xie, Jeffrey L Bennetzen, Liping Gao, Tao Xia, 2020, Discovery and characterization of tannase genes in plants: roles in hydrolysis of tannins, New Phytologist, 226:1104-1116
  2. Peiqiang Wang, Yajun Liu, Lingjie Zhang, Wenzhao Wang, Hua Hou, Yue Zhao, Xiaolan Jiang, Jie Yu, Huarong Tan, Yunsheng Wang, De‐Yu Xie*, LiPing Gao*, Tao Xia*, 2020, Functional demonstration of plant flavonoid carbocations proposed to be involved in the biosynthesis of proanthocyanidins. Plant Journal, 101:18-36.
  3. Dongming Ma, Saiprasad VS Gandra, Raman Manoharlal, Christophe La Hovary, De-Yu Xie (corresponding author), 2019, Untargeted metabolomics of Nicotiana tabacum grown in United States and India characterizes association of plant metabolomes with natural climate and geography. Frontiers in plant science,10: 1370, doi.org/10.3389/fpls.2019.01370.

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